Bi-polymeric Spongy Matrices Through Cross-linking Polymerization: Synthesized and Evaluated for Solubility Enhancement of Acyclovir

In this study, two hydrophilic polymers hydroxypropyl methyl cellulose and beta-cyclodextrin (?-CD) are used to synthesize highly responsive spongy polymeric matrices. Porous stimulus-responsive network was developed improve the solubility of acyclovir (ACV) at significant level. Grafting successfully carried out by free radical polymerization technique. Spongy matrices were characterized percentage entrapment efficiency, drug loading, studies, FTIR, powder X-ray diffraction, TGA, DSC, XRD, SEM, swelling in vitro studies. Acute oral toxicity studies conducted determine safety administration prepared HPMC-?CD-g-poly(AMPS) formulation. structures depicted SEM images. Complex formation thermal stability constituents analyzed DSC spectra. XRD analysis revealed reduction crystallinity Particle size optimized formulation found range 197 ± 2.55 nm. The momentous difference with reference product committed that release characteristics markedly enhanced Toxicity endorsed non-toxic compatible biological system. efficient method preparation, solubility, excellent physico-chemical characteristics, high dissolution, may be a promising approach for delivery poorly soluble drugs.